Yes, define is in the scrabble dictionary

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Define Definition

verb-transitive

To delineate the outline or form of: gentle hills that were defined against the sky.
from The American Heritage Dictionary of the English Language, 4th Edition
To describe the nature or basic qualities of; explain: define the properties of a new drug; a study that defines people according to their median incomes.
from The American Heritage Dictionary of the English Language, 4th Edition
To give form or meaning to: "For him, a life is defined by action” ( Jay Parini).
from The American Heritage Dictionary of the English Language, 4th Edition
To specify distinctly: define the weapons to be used in limited warfare.
from The American Heritage Dictionary of the English Language, 4th Edition
To state the precise meaning of (a word or sense of a word, for example).
from The American Heritage Dictionary of the English Language, 4th Edition

verb-intransitive

To make or write a definition.
from The American Heritage Dictionary of the English Language, 4th Edition

verb

To determine or identify the essential qualities or meaning of .
from Free Scrabble Dictionary
To discover and set forth the meaning of (as a word).
from Free Scrabble Dictionary
To create on a computer .
from Free Scrabble Dictionary
To fix or mark the limits of .
from Free Scrabble Dictionary
To make distinct, clear, or detailed especially in outline .
from Free Scrabble Dictionary

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Top Words by points

Points

infeed

10

2 letter words with DEFINE

Points

de

3

fe

5

en

2

ef

5

ed

3

id

3

if

5

in

2

ne

2

3 letter words with DEFINE

Points

fin

6

fie

6

fid

7

fen

6

fee

6

fed

7

nee

3

dee

4

end

4

def

7

den

4

die

4

dif

7

din

4

4 letter words with DEFINE

Points

nide

5

eide

5

neif

7

need

5

fine

7

find

8

fend

8

feed

8

defi

8

dene

5

deni

5

dine

5

5 letter words with DEFINE

Points

fiend

9

fined

9

diene

6

6 letter words with DEFINE

Points

infeed

10

define

10

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