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Yes, guise is in the scrabble dictionary

...and is worth 8 points by itself.

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Guise Definition

noun

False appearance; pretense: spoke to me under the guise of friendship.
Mode of dress; garb: huddled on the street in the guise of beggars.
Obsolete Custom; habit.
Outward appearance or aspect; semblance.
A customary way of speaking or behaving.

biographical name

3d Duc de 1550–1588 Fr. soldier & polit.
2d Duc de 1519–1563 Fr. soldier & polit.

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Here are some other words you could make with the letters GUISE

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Top Words by points

Points
guise

6

2 letter words with GUISE

Points

es

2

gi

3

is

2

si

2

us

2

3 letter words with GUISE

Points

gie

4

gis

4

sei

3

sig

4

sue

3

use

3

4 letter words with GUISE

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egis

5

gies

5

5 letter words with GUISE

Points

guise

6

Found 14 words in 0.16149 seconds