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Yes, lose is in the scrabble dictionary

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Lose Definition

verb-intransitive

To be defeated.
To operate or run slow. Used of a timepiece.
To suffer loss.

verb-transitive

To be deprived of (something one has had): lost her art collection in the fire; lost her job.
To be left alone or desolate because of the death of: lost his wife.
To be outdistanced by: chased the thieves but lost them.
To be unable to keep alive: a doctor who has lost very few patients.
To be unable to keep control or allegiance of: lost his temper at the meeting; is losing supporters by changing his mind.

verb

To bring to destruction.
source from Merriam-Webster
To miss from one's possession or from a customary or supposed place.
source from Merriam-Webster
To suffer deprivation of part with especially in an unforeseen or manner.
source from Merriam-Webster
To suffer loss through the death or removal of or final separation from (a person).
source from Merriam-Webster
To fail to keep control of or allegiance of.
source from Merriam-Webster

idiom

Lose it Slang To become deranged or mentally disturbed.
Lose it Slang To become less capable or proficient; decline.
Lose it Slang To lose control; blow up.
Lose out on To miss (an opportunity, for example).
Lose time To delay advancement.

phrasal-verb

Lose out To fail to achieve or receive an expected gain.

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Top Words by points

Points
lose

4

2 letter words with LOSE

Points

el

2

es

2

lo

2

oe

2

os

2

so

2

3 letter words with LOSE

Points

els

3

oes

3

ole

3

ose

3

sel

3

sol

3

4 letter words with LOSE

Points

lose

4

oles

4

sloe

4

sole

4

Found 16 words in 0.12868 seconds