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Yes, main is in the scrabble dictionary

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Main Definition

noun

A mainland.
Nautical A mainmast.
Nautical A mainsail.
Physical strength: fought with might and main.
The chief or largest part: His ideas are, in the main, impractical.

adjective

Exerted to the utmost; sheer: by main strength.
Grammar Of, relating to, or being the principal clause or verb of a complex sentence.
Most important; principal. See Synonyms at chief.
Nautical Connected to or located near the mainmast: a main skysail.
Obsolete Of or relating to a continuous area or stretch, as of land or water.

geographical name

River 325 (523 ) Germany rising in Bavaria in the Fichtelgebirge & flowing into the Rhine.
source from Merriam-Webster

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Top Words by points

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amin

6

2 letter words with MAIN

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am

4

na

2

mi

4

ma

4

in

2

an

2

ai

2

3 letter words with MAIN

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ami

5

ani

3

ain

3

aim

5

man

5

nam

5

nim

5

4 letter words with MAIN

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amin

6

main

6

mina

6

Found 17 words in 0.11632 seconds