Yes, mainline is in the scrabble dictionary

...and is worth 14 points by itself.

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Mainline Definition

adjective

Being in a principal or well-established position: the mainline churches.
from The American Heritage Dictionary of the English Language, 4th Edition
Being part of an established group.
from Free Scrabble Dictionary
Being in the .
from Free Scrabble Dictionary

verb-transitive

To inject (a drug, such as heroin) directly into a major vein.
from The American Heritage Dictionary of the English Language, 4th Edition

verb-intransitive

To inject a drug intravenously.
from The American Heritage Dictionary of the English Language, 4th Edition

verb

To take by or as if by injecting into a principal vein.
from Free Scrabble Dictionary
To mainline a narcotic drug.
from Free Scrabble Dictionary

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Top Words by points

Points

mainline

10

2 letter words with MAINLINE

Points

ae

2

ai

2

al

2

am

4

an

2

el

2

em

4

en

2

in

2

la

2

li

2

ma

4

me

4

mi

4

na

2

ne

2

3 letter words with MAINLINE

Points

ail

3

aim

5

ain

3

ale

3

ami

5

ane

3

ani

3

elm

5

inn

3

lam

5

lea

3

lei

3

lie

3

lin

3

mae

5

man

5

mel

5

men

5

mil

5

nae

3

nam

5

nan

3

nil

3

nim

5

4 letter words with MAINLINE

Points

alme

6

amen

6

amie

6

amin

6

anil

4

elan

4

ilea

4

ilia

4

inia

4

lain

4

lame

6

lane

4

lean

4

lien

4

lima

6

lime

6

limn

6

line

4

linn

4

mail

6

main

6

male

6

mane

6

meal

6

mean

6

mien

6

mile

6

mina

6

mine

6

mini

6

nail

4

name

6

nema

6

nine

4

5 letter words with MAINLINE

Points

alien

5

aline

5

amine

7

anile

5

anime

7

animi

7

elain

5

email

7

imine

7

inane

5

innie

5

leman

7

liane

5

liman

7

limen

7

linen

5

linin

5

maile

7

milia

7

minae

7

6 letter words with MAINLINE

Points

anilin

6

limina

8

maline

8

menial

8

7 letter words with MAINLINE

Points

aniline

7

laminin

9

lineman

9

melanin

9

8 letter words with MAINLINE

Points

mainline

10

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