Yes, nope is in the scrabble dictionary

...and is worth 8 points by itself.

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Nope Definition

adverb

Informal No.

Source: American Heritage Dictionary

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Here are some other words you could make with the letters NOPE

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Top Words by points	Points
nope	6

2 letter words with NOPE	Points
en	2
ne	2
no	2
oe	2
on	2
op	4
pe	4
po	4

3 letter words with NOPE	Points
eon	3
one	3
ope	5
pen	5

4 letter words with NOPE	Points
nope	6
open	6
peon	6
pone	6

Found 16 words in 0.10946 seconds