Yes, one is in the scrabble dictionary

...and is worth 4 points by itself.

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One Definition

noun

A one-dollar bill.
from The American Heritage Dictionary of the English Language, 4th Edition
A single person or thing; a unit: This is the one I like best.
from The American Heritage Dictionary of the English Language, 4th Edition
The cardinal number, represented by the symbol 1, designating the first such unit in a series.
from The American Heritage Dictionary of the English Language, 4th Edition
The number denoting unity.
from Free Scrabble Dictionary
The first in a set or series.
from Free Scrabble Dictionary

pronoun

An indefinitely specified individual: She visited one of her cousins.
from The American Heritage Dictionary of the English Language, 4th Edition
An unspecified individual; anyone: "The older one grows the more one likes indecencyā€¯ ( Virginia Woolf).
from The American Heritage Dictionary of the English Language, 4th Edition
A certain indefinitely indicated person or thing.
from Free Scrabble Dictionary
An individual of a vaguely indicated group anyone at all.
from Free Scrabble Dictionary
A single instance of a specified action.
from Free Scrabble Dictionary

idiom

At one In accord or unity.
from The American Heritage Dictionary of the English Language, 4th Edition
One and all Everyone.
from The American Heritage Dictionary of the English Language, 4th Edition
One by one Individually in succession.
from The American Heritage Dictionary of the English Language, 4th Edition

adjective

Being a single entity, unit, object, or living being.
from The American Heritage Dictionary of the English Language, 4th Edition
Being a single thing in contrast with or relation to another or others of its kind: One day is just like the next.
from The American Heritage Dictionary of the English Language, 4th Edition
Being the only individual of a specified or implied kind: the one person I could marry; the one horse that can win this race.
from The American Heritage Dictionary of the English Language, 4th Edition
Characterized by unity; undivided: They spoke with one voice.
from The American Heritage Dictionary of the English Language, 4th Edition
Forming a single entity of two or more components: three chemicals combining into one solution.
from The American Heritage Dictionary of the English Language, 4th Edition

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Top Words by points

Points

eon

3

2 letter words with ONE

Points

en

2

ne

2

no

2

oe

2

on

2

3 letter words with ONE

Points

eon

3

one

3

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