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Yes, opus is in the scrabble dictionary

...and is worth 8 points by itself.

find more words you can make below

Opus Definition

noun

A musical composition or set of compositions usually numbered in the order of its issue.
from Free Scrabble Dictionary

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Top Words by points

Points
opus

6

2 letter words with OPUS

Points

op

4

os

2

po

4

so

2

up

4

us

2

3 letter words with OPUS

Points

ops

5

pos

5

pus

5

sop

5

sou

3

sup

5

upo

5

ups

5

4 letter words with OPUS

Points

opus

6

soup

6

Found 16 words in 0.12147 seconds