Yes, poxiest is in the scrabble dictionary

...and is worth 17 points by itself.

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Poxiest Definition

adjective

Superlative form of poxy.
from the English-language Wiktionary

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Here are some other words you could make with the letters POXIEST, you can also
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Top Words by points

Points

exposit

16

2 letter words with POXIEST

Points

es

2

et

2

ex

9

is

2

it

2

oe

2

oi

2

op

4

os

2

ox

9

pe

4

pi

4

po

4

si

2

so

2

te

2

ti

2

to

2

xi

9

3 letter words with POXIEST

Points

est

3

its

3

oes

3

ope

5

ops

5

opt

5

ose

3

pes

5

pet

5

pie

5

pis

5

pit

5

pix

12

poi

5

pos

5

pot

5

pox

12

psi

5

pst

5

sei

3

set

3

sex

10

sip

5

sit

3

six

10

sop

5

sot

3

sox

10

tes

3

tie

3

tip

5

tis

3

tix

10

toe

3

top

5

xis

10

4 letter words with POXIEST

Points

epos

6

exit

11

expo

13

opes

6

opts

6

oxes

11

peso

6

pest

6

pets

6

pies

6

piso

6

pits

6

poet

6

pois

6

pose

6

post

6

pots

6

sept

6

sext

11

sipe

6

site

4

spit

6

spot

6

step

6

stop

6

ties

4

tips

6

toes

4

tope

6

topi

6

tops

6

5 letter words with POXIEST

Points

estop

7

exist

12

exits

12

expos

14

pesto

7

piste

7

pixes

14

poets

7

poise

7

posit

7

poxes

14

sexto

12

sixte

12

spite

7

stipe

7

stope

7

topes

7

topis

7

6 letter words with POXIEST

Points

postie

8

potsie

8

sexpot

15

sopite

8

7 letter words with POXIEST

Points

exposit

16

poxiest

16

Found 110 words in 0.27329 seconds