Yes, sliest is in the scrabble dictionary

...and is worth 7 points by itself.

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Sliest Definition

adjective

A superlative of sly.
from The American Heritage Dictionary of the English Language, 4th Edition

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Top Words by points

Points

islets

6

2 letter words with SLIEST

Points

es

2

ti

2

te

2

si

2

li

2

it

2

is

2

el

2

et

2

3 letter words with SLIEST

Points

est

3

tis

3

til

3

tie

3

tes

3

tel

3

sit

3

sis

3

set

3

sel

3

sei

3

els

3

lit

3

ess

3

lei

3

its

3

let

3

lie

3

lis

3

4 letter words with SLIEST

Points

sets

4

leis

4

silt

4

site

4

sits

4

slit

4

isle

4

ests

4

tels

4

ties

4

tile

4

tils

4

seis

4

sels

4

less

4

lest

4

lets

4

lies

4

list

4

lite

4

lits

4

5 letter words with SLIEST

Points

tiles

5

isles

5

islet

5

istle

5

stile

5

sties

5

slits

5

sites

5

silts

5

lists

5

lites

5

6 letter words with SLIEST

Points

islets

6

stiles

6

sliest

6

istles

6

Found 64 words in 0.16372 seconds