Yes, slyest is in the scrabble dictionary

...and is worth 9 points by itself.

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Slyest Definition

adjective

Superlative form of sly.
from the English-language Wiktionary

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Top Words by points

Points

slyest

9

2 letter words with SLYEST

Points

es

2

et

2

el

2

ye

5

te

2

3 letter words with SLYEST

Points

yet

6

yes

6

tye

6

tes

3

tel

3

sty

6

sly

6

set

3

sel

3

els

3

ess

3

est

3

let

3

ley

6

lye

6

4 letter words with SLYEST

Points

lyse

7

tyes

7

tels

4

ests

4

stye

7

stey

7

sets

4

sels

4

less

4

lest

4

lets

4

leys

7

lyes

7

5 letter words with SLYEST

Points

styes

8

style

8

lyses

8

6 letter words with SLYEST

Points

slyest

9

styles

9

Found 38 words in 0.16264 seconds