Yes, spite is in the scrabble dictionary

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Spite Definition

noun

An instance of malicious feeling.
from The American Heritage Dictionary of the English Language, 4th Edition
Malicious ill will prompting an urge to hurt or humiliate.
from The American Heritage Dictionary of the English Language, 4th Edition
Petty ill will or hatred with the disposition to irritate, annoy, or thwart.
from Free Scrabble Dictionary
An instance of spite.
from Free Scrabble Dictionary

idiom

In spite of Not stopped by; regardless of: They kept going in spite of their fears.
from The American Heritage Dictionary of the English Language, 4th Edition

verb-transitive

To annoy: He did it just to spite her.
from The American Heritage Dictionary of the English Language, 4th Edition
To fill with spite.
from The American Heritage Dictionary of the English Language, 4th Edition
To show spite toward.
from The American Heritage Dictionary of the English Language, 4th Edition
To vent spite on.
from The American Heritage Dictionary of the English Language, 4th Edition

verb

To fill with spite.
from Free Scrabble Dictionary
To treat maliciously (as by shaming or thwarting).
from Free Scrabble Dictionary

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Top Words by points

Points

piste

7

2 letter words with SPITE

Points

et

2

ti

2

te

2

si

2

pi

4

pe

4

it

2

es

2

is

2

3 letter words with SPITE

Points

sip

5

tis

3

tip

5

tie

3

tes

3

est

3

sit

3

its

3

set

3

sei

3

pes

5

pet

5

pst

5

pie

5

pis

5

pit

5

psi

5

4 letter words with SPITE

Points

step

6

tips

6

ties

4

spit

6

site

4

sipe

6

sept

6

pest

6

pets

6

pies

6

pits

6

5 letter words with SPITE

Points

piste

7

spite

7

stipe

7

Found 40 words in 0.1809 seconds