Yes, twain is in the scrabble dictionary

...and is worth 9 points by itself.

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Twain Definition

noun

Two.
from The American Heritage Dictionary of the English Language, 4th Edition

pronoun

Two fathoms .
from Free Scrabble Dictionary

biographical name

Mark .
from Free Scrabble Dictionary

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Top Words by points

Points

twain

8

2 letter words with TWAIN

Points

an

2

ti

2

ta

2

na

2

it

2

in

2

aw

5

at

2

ai

2

3 letter words with TWAIN

Points

ant

3

wit

6

win

6

wat

6

wan

6

twa

6

tin

3

taw

6

tan

3

nit

3

naw

6

ain

3

ait

3

awn

6

ani

3

4 letter words with TWAIN

Points

tain

4

tian

4

twin

7

anti

4

wain

7

wait

7

want

7

5 letter words with TWAIN

Points

twain

8

witan

8

Found 33 words in 0.14753 seconds