Yes, upstream is in the scrabble dictionary

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Upstream Definition

adjective

Business Closer to the point of production or manufacture than to the point of sale.
from The American Heritage Dictionary of the English Language, 4th Edition

adverb

In, at, or toward the source of a stream: paddling upstream.
from The American Heritage Dictionary of the English Language, 4th Edition

adverb or adjective

In the direction opposite to the flow of a stream.
from Free Scrabble Dictionary
In or to a position within the production stream closer to manufacturing processes .
from Free Scrabble Dictionary

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Top Words by points

Points

tempuras

12

2 letter words with UPSTREAM

Points

ae

2

am

4

ar

2

as

2

at

2

em

4

er

2

es

2

et

2

ma

4

me

4

mu

4

pa

4

pe

4

re

2

ta

2

te

2

um

4

up

4

us

2

ut

2

3 letter words with UPSTREAM

Points

amp

7

amu

5

ape

5

apt

5

are

3

arm

5

ars

3

art

3

asp

5

ate

3

ats

3

ear

3

eat

3

eau

3

ems

5

emu

5

era

3

ers

3

est

3

eta

3

mae

5

map

7

mar

5

mas

5

mat

5

met

5

mus

5

mut

5

pam

7

par

5

pas

5

pat

5

pea

5

per

5

pes

5

pet

5

pst

5

pur

5

pus

5

put

5

ram

5

rap

5

ras

3

rat

3

rem

5

rep

5

res

3

ret

3

rue

3

rum

5

rut

3

sae

3

sap

5

sat

3

sau

3

sea

3

ser

3

set

3

spa

5

sue

3

sum

5

sup

5

tae

3

tam

5

tap

5

tar

3

tas

3

tau

3

tea

3

tes

3

tum

5

tup

5

ump

7

ums

5

ups

5

urp

5

use

3

uta

3

ute

3

uts

3

4 letter words with UPSTREAM

Points

amps

8

amus

6

aper

6

apes

6

apse

6

ares

4

arms

6

arts

4

arum

6

ates

4

ears

4

east

4

eats

4

emus

6

eras

4

erst

4

etas

4

maes

6

maps

8

mare

6

mars

6

mart

6

mast

6

mate

6

mats

6

maut

6

meat

6

mesa

6

meta

6

mura

6

mure

6

muse

6

must

6

mute

6

muts

6

pams

8

pare

6

pars

6

part

6

pase

6

past

6

pate

6

pats

6

pear

6

peas

6

peat

6

perm

8

pert

6

pest

6

pets

6

pram

8

prat

6

prau

6

puma

8

pure

6

purs

6

puts

6

ramp

8

rams

6

rape

6

raps

6

rapt

6

rase

4

rasp

6

rate

4

rats

4

ream

6

reap

6

rems

6

reps

6

rest

4

rets

4

rues

4

rump

8

rums

6

ruse

4

rust

4

ruts

4

same

6

samp

8

sate

4

seam

6

sear

4

seat

4

sept

6

sera

4

seta

4

smut

6

spae

6

spam

8

spar

6

spat

6

spue

6

spur

6

star

4

stem

6

step

6

stum

6

suer

4

suet

4

sump

8

supe

6

sura

4

sure

4

tame

6

tamp

8

tams

6

tape

6

taps

6

tare

4

tarp

6

tars

4

tase

4

taus

4

team

6

tear

4

teas

4

temp

8

tepa

6

term

6

tram

6

trap

6

trem

6

true

4

tsar

4

tump

8

tums

6

tups

6

umps

8

upas

6

urea

4

urps

6

ursa

4

user

4

utas

4

utes

4

5 letter words with UPSTREAM

Points

amuse

7

apers

7

apres

7

apter

7

armet

7

arums

7

asper

7

aster

5

aures

5

erupt

7

mares

7

marse

7

marts

7

maser

7

mater

7

mates

7

mauts

7

meats

7

muras

7

mures

7

muser

7

muter

7

mutes

7

pares

7

pareu

7

parse

7

parts

7

paste

7

pater

7

pates

7

pause

7

pears

7

peart

7

peats

7

perms

9

prams

9

prase

7

prate

7

prats

7

praus

7

presa

7

prest

7

pruta

7

pumas

9

purse

7

ramet

7

ramps

9

ramus

7

rapes

7

rates

5

reams

7

reaps

7

remap

9

resat

5

rumps

9

satem

7

saute

5

septa

7

serum

7

setup

7

smart

7

smear

7

spare

7

spate

7

spear

7

sperm

9

sprat

7

sprue

7

spume

9

spurt

7

sputa

7

stamp

9

stare

5

steam

7

strap

7

strep

7

strum

7

stump

9

stupa

7

stupe

7

super

7

supra

7

sutra

5

tamer

7

tames

7

tamps

9

taper

7

tapes

7

tares

5

tarps

7

taupe

7

teams

7

tears

5

temps

9

tepas

7

terms

7

tramp

9

trams

7

traps

7

trems

7

trues

5

trump

9

tumps

9

turps

7

upset

7

urase

5

urate

5

ureas

5

ursae

5

6 letter words with UPSTREAM

Points

amuser

8

armets

8

erupts

8

estrum

8

master

8

maters

8

matres

8

mature

8

meatus

8

muster

8

mutase

8

pareus

8

paster

8

paters

8

pauser

8

prates

8

purest

8

ramets

8

remaps

10

repast

8

septum

10

stream

8

struma

8

tamers

8

tamper

10

tapers

8

taupes

8

tramps

10

trapes

8

trumps

10

uprate

8

uptear

8

urates

6

7 letter words with UPSTREAM

Points

matures

9

pasture

9

restamp

11

stamper

11

strumae

9

stumper

11

sumpter

11

tampers

11

tempura

11

uprates

9

upstare

9

uptears

9

8 letter words with UPSTREAM

Points

tempuras

12

upstream

12

Found 393 words in 0.29052 seconds