Yes, woe is in the scrabble dictionary

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Woe Definition

noun

Deep distress or misery, as from grief; wretchedness. See Synonyms at regret.
Misfortune; calamity: economic and political woes.
A condition of deep suffering from misfortune, affliction, or grief.
Ruinous trouble.

interjection

Used to express sorrow or dismay.

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owe

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2 letter words with WOE

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ew

5

oe

2

ow

5

we

5

wo

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3 letter words with WOE

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owe

6

woe

6

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